Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations (NOT-OD-26-012)
Continuation of Modifications to Peer Review Practices NOT-OD-26-069
Modifications will remain in place for the October 2026 Advisory Council
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Updated Elements of an NIH Data Management and Sharing Plan NOT-OD-26-046
- NIH is revising DMS Plan elements and requiring the use of the corresponding revised format page to aid compliance monitoring
- Updated DMS Plan Format page will be made available upon receipt of OMB clearance – see Draft at Data Management and Sharing Plan Format Page
- Effective for applications submitted for due dates on or after May 25,2026
- Implementing this updated format page as a pilot and will evaluate the need for additional updates over the next year
SciENcv is the only option for preparing the NIH biosketch and Current & Pending (Other) Support documents for applications
> Common Forms for Biographical Sketch and Current and Pending (Other) Support
> Biographical Sketch Common Form
> NIH Biographical Sketch Supplement
- SciENcv LOGIN
- SciENcv Guide
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Updates to Finding NIH Funding Opportunities and Information
On this page:
- Recognizing Grants.gov as the Single Official Source for NIH Grant and Cooperative Agreement Funding Opportunities
- Overall Reduction in Number of NIH NOFOs
- Consolidation of NIH Grants and Funding Information
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Implementation of New Initiatives and Policies
This page serves as a central location for information about changes impacting NIH grants process and plans for implementing new initiatives and policies.
See also: Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions
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**Use of AI in Application Preparation and Review is not allowed**
Supporting Fairness and Originality in NIH Research Applications NOT-OD-25-132
NIH will not consider applications that are either substantially developed by AI, or contain sections substantially developed by AI, to be original ideas of applicants.
- If the detection of AI is identified post award, NIH may refer the matter to the Office of Research Integrity to determine whether there is research misconduct while simultaneously taking enforcement actions including but not limited to disallowing costs, withholding future awards, wholly or in part suspending the grant, and possible termination.
- NIH will only accept six new, renewal, resubmission, or revision applications from an individual Principal Investigator/Program Director or Multiple Principal Investigator for all council rounds in a calendar year.
This policy applies to all activity codes except T activity codes and R13 Conference Grant Applications. Based on recent data, this limit will affect a relatively small number of Principal Investigators while enabling the NIH to maintain consistently high-quality grant application review and appropriately steward taxpayer dollars.
- NIH issued a notice prohibiting the use of generative AI technologies in the peer review process. This includes using large language models, natural language processors, and other AI technologies for developing peer review critiques for contracts and grant applications.
- Reviewers will be required to sign and submit an agreement certifying that they understand and will abide by these requirements.
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NIH Grants Process: A Brief Walk-Through for Beginners -- slides and video
Resources and Programs for NIH Grant Applicants
An infographic from the Center for Scientific Review to help clarify the process that highlights institution- and investigator-specific information, including key actions that must be taken well in advance of application submission
Early Stage Investigator (ESI) Policies and Resources
Artificial Intelligence
Policy Considerations and Guidance re: Research Participant Protections; Data Management and Sharing; Health Information Privacy; Licensing, Intellectual Property, & Technology Transfer; Peer Review; and Biosecurity and Biosafety PLUS additional resources for researchers
See also: Supporting Fairness and Originality in NIH Research Applications NOT-OD-25-132
Comparing Popular Research Project Grants: R01, R03 or R21 (NIAID)
Find a Fit for Your Research: NIH Institutes, Centers, and Offices (ICOs)
Researchers can use the NIH-specific filters in this search tool to quickly identify potential funding opportunities of interest in Grants.gov.
> Starting in October 2025, Grants.gov is the single official source for NIH grant opportunities.
Use Grants.gov Subscriptions for notifications of new opportunities.
> Search Tips for NIH Opportunities
Highlighted Topics
Each topic represents a selected research priority area within one or more NIH Institutes, Centers, or Offices (ICOs) that may or may not have dedicated funding.
So, I’m Interested in a Highlighted Topic…What Do I Do Now?
Subscribe to receive notices of new topics
PARENT ANNOUNCEMENTS (For Unsolicited or Investigator-Initiated Applications)
Standard Due Dates
Write Application
Find the official grant application instructions, preview application forms, get advice on grant writing, check out sample grant applications, and read our tips on specific application attachments and sections. This guidance can help you develop a strong application that allows reviewers to better evaluate the science and merit of your proposal.
How to Apply - Application Guide
Format Attachments
Page Limits
Data Tables for use with Institutional Research Training grant applications, etc.
Biosketches
MyBibliography User Guide
NOT-OD-25-152: Preview of NIH Common Forms for Biographical Sketch and Current and Pending (Other) Support
Coming Soon to SciENcv
Note:
> All Senior/Key Personnel listed on the R&R Profile form must have an eRA Commons ID
> All Senior/Key Personnel listed on the R&R Profile form need to have an ORCID ID linked to their eRA Commons account to use the new Common Forms for Biosketch
Develop Your Budget
Definition of Human Subjects Research
Basic Experimental Studies Involving Humans (BESH)
Basic Experimental Studies in Humans (BESH) Will No Longer Be Considered Clinical Trials by the NIH
Implementation of Changes for Basic Experimental Studies with Humans
Division of Human Subjects Research (DHSR) Resources on Human Subjects, Clinical Trials, and Inclusion
Allowable Costs Related to Participant Inclusion Activities
NIH Data Management and Sharing Policy
Updated Elements of an NIH Data Management and Sharing Plan (NOT-OD-26-046)
Effective for applications submitted for due dates on or after May 25, 2026, applicants and recipients are required to utilize a new, simpler format (see link below).
This Guide Notice also updates DMS Plan elements to clarify common areas of confusion in the research community while streamlining and simplifying DMS Plans.
Data Management and Sharing Plan Format Page (current and new versions)
NIH ADVICE
Write Your Application
Samples: Applications and Documents
Tips for Tables, Charts, and Figures
Virtual NIH Grants Conference on Funding, Policies, and Processes (February 1-2, 2023)
Videos, slides, and transcripts from conference and pre-conference presentations
Center for Scientific Review - Applicant Resources
Resources and Programs for NIH Grant Applicants
Assisted Referral Tool (ART) - a tool to recommend a potentially appropriate study section
What Happens to Your Application - infographic
What Happens to Your Application - video
NIH Peer Review: Grants and Cooperative Agreements
A ”one-stop explanation of the core values of peer review and the NIH policies that uphold them”
Planning and Writing
Reviewer Guidance on Rigor and Transparency
Apply for a Grant (NIAID)
This comprehensive guide covers all aspects of seeking funding: finding opportunities, interacting with NIH, application preparation, review, and more.
Includes sample applications and summary statements for some funding mechanisms
For other resources, see RD Digital Library >> NIH -- National Institutes of Health
