Mass Spectrometer - Ascend LC-MS

The Thermo Orbitrap Ascend Tribrid is a high-resolution mass spectrometer that is capable of operating over an extended mass range of m/z 40 - 16,000 and is coupled with a Vanquish Neo UHPLC system to perform LC-MS analysis.  The instrument is capable of up to 480,000 FWHM mass resolving power (at m/z 200), a < 1 ppm mass error, and offers sensitivities on the order of femtograms.  The detector also allows for a large dynamic range of up to >5,000, with the instrument electronics capable of high scan rates and polarity switching.  In addition, the instrument is upgraded with a high field asymmetric waveform ion mobility spectrometry (FAIMS) module for enhanced ion separation at the instrument inlet, as well as Easy-ETD and UVPD ion sources within the instrument for enhanced fragmentation in order to better elucidate molecular structures of large molecules.  Both heated electrospray and nanospray flex ion sources are available for the Ascend Mass Spectrometer, offering a wide range of flow rates (μL to nL) for sample introduction.

Ascend LC-MS
Manufacturer: Thermofisher Scientific
Instrument name: Thermo Vanquish Neo UHPLC and Thermo Orbitrap Ascend Tribrid MS
Year acquired: 2024
Location: Parsons Hall, Room W118

Principal Scientist:  Philip Place

The Thermo Scientific Orbitrap Ascend Tribrid electrospray ionization mass spectrometer with Vanquish Neo ultra-high pressure liquid chromatography system (UPLC ESI-MS) is managed by the University Instrumentation Center (UIC) and was purchased with funds awarded to the University of New Hampshire (UNH) by the US National Science Foundation (NSF) (MRI Grant 2320241).


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Contact Information

Philip Place
Parsons Hall Rm W123E
Durham, NH 03824
(603) 862-1030


UNH Rates:
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Non-UNH Academic Rate:
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Industry Rate:
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