Publications

...

2023 Publications

Ahmad HMN, Andrade A, Song E. Continuous Real-Time Detection of Serotonin Using an Aptamer-Based Electrochemical Biosensor. Biosensors (Basel). 2023 Nov 13;13(11). doi: 10.3390/bios13110983. PubMed PMID: 37998158; PubMed Central PMCID: PMC10669129.

Bubli SY, Smolag M, Blackwell E, Lin YC, Tsavalas JG, Li L. Inducing an LCST in hydrophilic polysaccharides via engineered macromolecular hydrophobicity. Sci Rep. 2023 Sep 9;13(1):14896. doi: 10.1038/s41598-023-41947-z. PubMed PMID: 37689784; PubMed Central PMCID: PMC10492858.

Fleck K, McNutt S, Chu F, Jeffers V. An apicomplexan bromodomain protein, TgBDP1, associates with diverse epigenetic factors to regulate essential transcriptional processes in Toxoplasma gondii. mBio. 2023 Jun 23:e0357322. doi: 10.1128/mbio.03573-22. Epub ahead of print. PMID: 37350586.

Tripathi S, Cote RH, Vashisth H. Coupling of conformational dynamics and inhibitor binding in the phosphodiesterase-5 family. Protein Sci. 2023 Aug;32(8):e4720. doi: 10.1002/pro.4720. PMID: 37407431; PMCID: PMC10367598.

Peng YJ, Nanduri J, Wang N, Kumar GK, Bindokas V, Paul BD, Chen X, Fox AP, Vignane T, Filipovic MR, Prabhakar NR. Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78. Sci Adv. 2023 Jul 7;9(27):eadf3026. doi: 10.1126/sciadv.adf3026. Epub 2023 Jul 5. PMID: 37406126; PMCID: PMC10321732.

Zayka P, Parr B, Robichaud H, Hickey S, Topping A, Holt E, Watts DBE, Soto N, Stein DC, DeShong P, Hurley M. Evaluating methods to create protein functionalized catanionic vesicles. Soft Matter. 2023 Feb 15;19(7):1429-1439. doi: 10.1039/d2sm01205g. PMID: 36723251.

Moser B, Moore D, Khadka B, Lyons C, Foxall T, Andam CP, Parker CJ, Ochin C, Garelnabi M, Sevigny J, Thomas WK, Bigornia S, Dao MC. Association between inflammation, lipopolysaccharide binding protein, and gut microbiota composition in a New Hampshire Bhutanese refugee population with a high burden of type 2 diabetes. Front Nutr. 2023 Jan 6;9:1059163. doi: 10.3389/fnut.2022.1059163. PMID: 36687728; PMCID: PMC9852993.

2022 Publications

Irwin, M. J., et al. (2022). "Reconstitution of membrane-associated components of a G-protein signaling pathway on membrane-coated nanoparticles (lipobeads)." bio-protocol 12(2): e4303.

Sreter, J.A., Foxall, T.L., Varga, K. (2022). Intracellular and Extracellular Antifreeze Protein Significantly Improves Mammalian Cell Cryopreservation. Biomolecules, 12(5): 669. https://doi.org/10.3390/biom12050669

Spurgeon ME, Cheng J, Ward-Shaw E, Dick FA, DeCaprio JA, Lambert PF. Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development. PLoS Pathog. 2022 May 13;18(5):e1010551. doi: 10.1371/journal.ppat.1010551. PMID: 35560034; PMCID: PMC9132321.

Panahi Z, Ren T, Halpern JM. Nanostructured Cyclodextrin-Mediated Surface for Capacitive Determination of Cortisol in Multiple Biofluids. ACS Appl Mater Interfaces. 2022 Aug 2. doi: 10.1021/acsami.2c07701. Epub ahead of print. PMID: 35918826.

Andrzejczyk J, Jovic K, Brown LM, Pascetta VG, Varga K, Vashisth H. Molecular interactions and inhibition of the SARS-CoV-2 main protease by a thiadiazolidinone derivative. Proteins. 2022 Nov;90(11):1896-1907. doi: 10.1002/prot.26385. Epub 2022 Jun 3. PMID: 35567429; PMCID: PMC9347825.

Edwards SD, Hou S, Brown JM, Boudreau RD, Lee Y, Kim YJ, Jeong KJ. Fast-Curing Injectable Microporous Hydrogel for In Situ Cell Encapsulation. ACS Appl Bio Mater. 2022 May 16. doi: 10.1021/acsabm.2c00214. Epub ahead of print. PMID: 35576622.

Matissek SJ, Karbalivand M, Han W, Boutilier A, Yzar-Garcia E, Kehoe LL, Gardner DS, Hage A, Fleck K, Jeffers V, Rajsbaum R, Elsawa SF. A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling. Oncotarget. 2022 Aug 3;13:944-959. doi: 10.18632/oncotarget.28261. PMID: 35937499; PMCID: PMC9348707.

Nadar, P.M., Merrill, M.A., Austin, K. et al. The emergence of psychoanalytical electrochemistry: the translation of MDD biomarker discovery to diagnosis with electrochemical sensing. Transl Psychiatry 12, 372 (2022). https://doi.org/10.1038/s41398-022-02138-y

Boutilier AJ, Huang L, Elsawa SF. Waldenström Macroglobulinemia: Mechanisms of Disease Progression and Current Therapies. Int J Mol Sci. 2022 Sep 22;23(19):11145. doi: 10.3390/ijms231911145. PMID: 36232447; PMCID: PMC9569492.

Robison, C. L., Cova, N., Madore, V., Allen, T., Barrett, S., & Charntikov, S. (2022, October 21). Assessment of ethanol and nicotine interactions using a reinforcer demand modeling with grouped and individual levels of analyses in a long-access self-administration model. bioRxiv. Retrieved October 25, 2022, from https://www.biorxiv.org/content/10.1101/2022.10.17.512519v1

 

T. Ren, S.E. Bramlitt, J.M.J. Lafreniere, W.R. Seitz, J.M. Halpern§. “Conformation-Based Stimuli-Response Sensors: Strategies for Optimizing Electrochemical and FRET Transduction”, Sensors and Actuators Reports. 3, (2021), 100066. doi: 10.1016/j.snr.2021.100066

Fleck K, Nitz M, Jeffers V (2021) “Reading” a new chapter in protozoan parasite transcriptional regulation. PLOS Pathogens 17(12): e1010056. https://doi.org/10.1371/journal.ppat.1010056 "

Joh, YA, Kwon, YH, Tannir, S, Leonard, BM, Kubelka, J, Varga, K, and Balaz, M; The effect of molecular isomerism on the induced circular dichroism of cadmium sulfide quantum dots. J Mater Chem C (2021), 9: 17483-17495. https://doi.org/10.1039/D1TC04496F "

Z. Panahi, L. Custer, J. M. Halpern, Recent advances in non-enzymatic electrochemical detection of hydrophobic metabolites in biofluids. Sensors and Actuators Reports. 3 (2021), doi:10.1016/j.snr.2021.100051.

Cote, Rick H.; Gupta, Richa; Irwin, Michael J.; and Wang, Xin, "Photoreceptor phosphodiesterase (PDE6): structure, regulatory mechanisms, and implications for treatment of retinal diseases" (2021). Adv Exp Med Biol. Protein Reviews. 1236.

"Stanley G. Feeney, Joelle M. J. LaFreniere, Jeffrey Mark Halpern, Perspective on Nanofiber Electrochemical Sensors: Design of Relative Selectivity Experiments Polymers (Basel) 2021 Nov; 13(21): 3706. Published online 2021 Oct 27. doi: 10.3390/polym13213706 PMCID: PMC8588248"

Cheng, MLH, Lippmann, TC, Dijkstra, JA, Bradt, G, Cook, S, Choi, J-G, Brown, BL. (2021). A Deposition Baseline for Microplastic Particle Distribution in an Estuary. Marine Pollution Bulletin. 170. doi: 10.1016/j.marpolbul.2021.112653.

Maran SR, Fleck K, Monteiro-Teles NM, Isebe T, Walrad P, Jeffers V, Cestari I, Vasconcelos EJR, Moretti N. Protein acetylation in the critical biological processes in protozoan parasites. Trends Parasitol. 2021 Sep;37(9):815-830. doi: 10.1016/j.pt.2021.04.008. Epub 2021 May 12. PMID: 33994102.

Boutilier AJ, Elsawa SF. Macrophage Polarization States in the Tumor Microenvironment. Int J Mol Sci. 2021 Jun 29;22(13):6995. doi: 10.3390/ijms22136995. PMID: 34209703; PMCID: PMC8268869.

Nadide Altincekic, Sophie M., Korn, Nusrat S. Qureshi et al., Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Front. Mol. Biosci. 8:653148 (2021), doi:10.3389/fmolb.2021.653148.

E.C. Yip, I. Miko, J.M. Ulmer, N.A. Cherim, M.A. Townley, S. Poltak, A.M. Helms, C.M. De Moraes, M.C. Mescher & J.F. Tooker (2021). Giant polyploid epidermal cells and male pheromone production in the tephritid fruit fly Eurosta solidaginis (Diptera: Tephritidae). Journal of Insect Physiology 130: 104210. DOI: 10.1016/j.jinsphys.2021.104210

LaFreniere JMJ, Roberge EJ, Ren T, Seitz WR, Balog ERM, Halpern JM. Insights on the Lower Critical Solution Temperature Behavior of pNIPAM in an Applied Electric Field. ECS Trans. 2020;97(7):709-715. doi: 10.1149/09707.0709ecst. PMID: 33796207; PMCID: PMC8011545.

Ziino ER, Marnoto S, Halpern JM. Investigation to Minimize Electrochemical Impedance Spectroscopy Drift. ECS Trans. 2020;97(7):737-745. doi: 10.1149/09707.0737ecst. PMID: 33777309; PMCID: PMC7996669.

Liu Y, Vashisth, H. Allosteric Pathways Originating at Cysteine Residues in Regulators of G-protein Signaling Proteins Biophys. J. 120:517-526 (2021); doi: 10.1016/ j.bpj.2020.12.010

Hart E, Hertia D, Barrett ST, Charntikov S. Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement. BEHAVIOURAL BRAIN RESEARCH 397 Article number ARTN 112887 15 Jan 2021 doi:10.1016/j.bbr.2020.112887

Ahmad HMN, Dutta G, Csoros J, Si B, Yang R, Halpern JM, Seitz WR, Song E. Stimuli-Responsive Templated Polymer as a Target Receptor for a Conformation-based Electrochemical Sensing Platform. ACS Appl Polym Mater. 2021 Jan 8;3(1):329-341. doi: 10.1021/acsapm.0c01120. Epub 2020 Dec 9. PMID: 33748761; PMCID: PMC7971449.

Panahi, Z., Merrill, M. A.; Halpern, J. M. (2020). Reusable Cyclodextrin-Based Electrochemical Platform for Detection of trans-Resveratrol. ACS Applied Polymer Materials. doi:10.1021/acsapm.0c00866 Nadide Altincekic, Sophie M., Korn, Nusrat S. Qureshi et al., Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Front. Mol. Biosci. 8:653148 (2021), doi:10.3389/fmolb.2021.653148. E.C. Yip, I. Miko, J.M. Ulmer, N.A. Cherim, M.A. Townley, S. Poltak, A.M. Helms, C.M. DeMoraes, M.C. Mescher & J.F. Tooker (2021). Giant polyploid epidermal cells and male pheromone production in the tephritid fruit fly Eurosta solidaginis (Diptera: Tephritidae). Journal of Insect Physiology 130: 104210. DOI: 10.1016/j.jinsphys.2021.104210" LaFreniere JMJ, Roberge EJ, Ren T, Seitz WR, Balog ERM, Halpern JM. Insights on the Lower Critical Solution Temperature Behavior of pNIPAM in an Applied Electric Field. ECS Trans. 2020;97(7):709-715. doi: 10.1149/09707.0709ecst. PMID: 33796207; PMCID: PMC8011545. Ziino ER, Marnoto S, Halpern JM. Investigation to Minimize Electrochemical Impedance Spectroscopy Drift. ECS Trans. 2020;97(7):737-745. doi: 10.1149/09707.0737ecst. PMID: 33777309; PMCID: PMC7996669. Liu Y, Vashisth, H. Allosteric Pathways Originating at Cysteine Residues in Regulators of G-protein Signaling Proteins Biophys. J. 120:517-526 (2021); doi: 10.1016/ j.bpj.2020.12.010 Hart E, Hertia D, Barrett ST, Charntikov S. Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement. BEHAVIOURAL BRAIN RESEARCH 397 Article number ARTN 112887 15 Jan 2021 doi:10.1016/j.bbr.2020.112887 Ahmad HMN, Dutta G, Csoros J, Si B, Yang R, Halpern JM, Seitz WR, Song E. Stimuli-Responsive Templated Polymer as a Target Receptor for a Conformation-based Electrochemical Sensing Platform. ACS Appl Polym Mater. 2021 Jan 8;3(1):329-341. doi: 10.1021/acsapm.0c01120. Epub 2020 Dec 9. PMID: 33748761; PMCID: PMC7971449. Matissek, SJ, Han, W, Hage, A, Karbalivand, M, Rajsbaum, R and Elsawa, SF (2020). A novel mechanism of regulation of the transcription factor GLI3 by toll-like receptor signaling. JLB. (submitted; BioRxiv DOI: 10.1101/2021.01.01.424866). Matissek SJ, Han W, Karbalivand M, Sayed M, Reilly BM, Mallat S, Ghazal SM, Munshi M, Yang G, Treon SP, Walker SR, Elsawa SF. Epigenetic targeting of Waldenström macroglobulinemia cells with BET inhibitors synergizes with BCL2 or histone deacetylase inhibition. Epigenomics Epigenomics. 2021 Jan; 13(2): 129–144. Published online 2020 Dec 24. doi: 10.2217/epi-2020-0189 Nordyke, CT.; Ahmed, YM.; Puterbaugh, RZ.; Bowman, GR.; Varga, K; Intrinsically Disordered Bacterial Polar Organizing Protein Z, PopZ, Interacts with Protein Binding Partners Through an N-terminal Molecular Recognition Feature, Journal of molecular biology 432(23):6092-6107 Nov 2020 doi: 10.1016/j.jmb.2020.09.020. Robison, C. L., Kazan, T., Miller, R., Cova, N., & Charntikov, S. (2020). Inactivation of posterior but not anterior dorsomedial caudate-putamen impedes learning with self-administered nicotine stimulus. BioRxiv. https://doi.org/10.1101/2020.08.28.271908 Yang J, Qiu L, Strobel M, Kabel A, Zha X, and Chen X. Acid-Sensing Ion Channels Mediate Type III Adenylyl Cyclase-Independent Acid-Sensing of Mouse Olfactory Sensory Neurons. Mol Neurobiol. 2020 Jul;57(7):3042-3056. doi: 10.1007/s12035-020-01943-0. Epub 2020 May 26. Toran PT, Wohlfahrt M, Foye J, Kiem HP, Wojchowski DM. Assessment and streamlined preparation of low-cytotoxicity lentiviral vectors for mobilized human hematopoietic stem cell transduction. Exp Hematol. 2020 Jun;86:28-42.e3. doi: 10.1016/j.exphem.2020.05.009. Epub 2020 May 27. PubMed PMID: 32473295; PubMed Central PMCID: PMC7372909.

Irwin MJ, Gupta R, Gao XZ, Cahill KB, Chu F, Cote RH. The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation. J Biol Chem. 2019 Nov 5;. doi: 10.1074/jbc.RA119.011002. [Epub ahead of print] PubMed PMID: 31690623.

Shaw VS, Mohammadi M, Quinn JA, Vashisth H, Neubig RR. An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency For Regulators of G-protein Signaling (RGS) Proteins 4, 8, and 19. Mol Pharmacol. 2019 Sep 22;. doi: 10.1124/mol.119.117176. [Epub ahead of print] PubMed PMID: 31543506.

Chu F, Hogan D, Gupta R, Gao XZ, Nguyen HT, Cote RH. Allosteric Regulation of Rod Photoreceptor Phosphodiesterase 6 (PDE6) Elucidated by Chemical Cross-Linking and Quantitative Mass Spectrometry. J Mol Biol. 2019 Sep 6;431(19):3677-3689. doi: 10.1016/j.jmb.2019.07.035. Epub 2019 Aug 5. PubMed PMID: 31394113; PubMed Central PMCID: PMC6733632.

Stafford NP, Kazan TN, Donovan CM, Hart EE, Drugan RC, Charntikov S. Individual Vulnerability to Stress Is Associated With Increased Demand for Intravenous Heroin Self-administration in Rats. Front Behav Neurosci. 2019;13:134. doi: 10.3389/fnbeh.2019.00134. eCollection 2019. PubMed PMID: 31293400; PubMed Central PMCID: PMC6603087.

Wang X, Plachetzki DC, Cote RH. The N termini of the inhibitory γ-subunits of phosphodiesterase-6 (PDE6) from rod and cone photoreceptors differentially regulate transducin-mediated PDE6 activationJ Biol Chem. 2019 May 24;294(21):8351-8360. doi: 10.1074/jbc.RA119.007520. Epub 2019 Apr 8. PubMed PMID: 30962282; PubMed Central PMCID: PMC6544851.

Kazan T, Charntikov S. Individual differences in responding to bupropion or varenicline in a preclinical model of nicotine self-administration vary according to individual demand for nicotine. Neuropharmacology. 2019 Apr;148:139-150. doi: 10.1016/j.neuropharm.2018.12.031. Epub 2019 Jan 3. PubMed PMID: 30611697; PubMed Central PMCID: PMC6457454.

Park S, Edwards S, Hou S, Boudreau R, Yee R, Jeong KJ. A multi-interpenetrating network (IPN) hydrogel with gelatin and silk fibroin. Biomaterials science. 2019 March 26;7(4):1276-1280. PubMed PMID: 30672521; PubMed Central PMCID: PMC6435401

Zhou Y, Qiu L, Sterpka A, Wang H, Chu F, Chen X. Comparative Phosphoproteomic Profiling of Type III Adenylyl Cyclase Knockout and Control, Male, and Female Mice. Frontiers in cellular neuroscience. 2019 February 13;13:34. PubMed PMID: 30814930;
PubMed Central PMCID: PMC6381875.

Mohammadi M, Mohammadiarani H, Shaw VS, Neubig RR, Vashisth H. Interplay of cysteine exposure and global protein dynamics in small-molecule recognition by a regulator of G-protein signaling protein. Proteins. 2019 February;87(2):146-156. PubMed PMID: 30521141; PubMed Central PMCID: PMC6387623.

Sterpka A, Chen X. Neuronal and astrocytic primary cilia in the mature brain. Pharmacol Res. 2018 Nov;137:114-121. doi: 10.1016/j.phrs.2018.10.002. Epub 2018 Oct 4. Review. PubMed PMID: 30291873; PubMed Central PMCID: PMC6410375.

Morales MA, Halpern JM. Guide to Selecting a Biorecognition Element for Biosensors. Bioconjug Chem. 2018 Oct 17;29(10):3231-3239. doi: 10.1021/acs.bioconjchem.8b00592. Epub 2018 Sep 28. Review. PubMed PMID: 30216055; PubMed Central PMCID: PMC6416154.
Hou S, Lake R, Park S, Edwards S, Jones C, Jeong KJ. Injectable Macroporous Hydrogel Formed by Enzymatic Cross-Linking of Gelatin Microgels. ACS Appl. Bio Mater.. 2018 October; 1(5):1430-1439. NIHMSID: NIHMS1013263.
Dinh TN, Hou S, Park S, Shalek BA, Jeong KJ. Gelatin Hydrogel Combined with Polydopamine Coating to Enhance Tissue Integration of Medical Implants. ACS Biomater Sci Eng. 2018 Oct 8;4(10):3471-3477. doi: 10.1021/acsbiomaterials.8b00886. Epub 2018 Sep 12. PubMed PMID: 31131316; PubMed Central PMCID: PMC6533074.
Tooley CA, Gasperoni CH, Marnoto S, Halpern JM. Evaluation of Metal Oxide Surface Catalysts for the Electrochemical Activation of Amino AcidsSensors (Basel). 2018 Sep 18;18(9). doi: 10.3390/s18093144. PubMed PMID: 30231497; PubMed Central PMCID: PMC6164431
Charntikov, S., Pittenger, S. T., Pudiak, C. M., & Bevins, R. A. (2018). The effect of N-acetylcysteine or bupropion on methamphetamine self-administration and methamphetamine-triggered reinstatement of female rats. Neuropharmacology, 135, 487–495. doi:10.1016/j.neuropharm.2018.03.021
Ghosh S, Khan NI, Tsavalas JG, Song E. Selective Detection of Lysozyme Biomarker Utilizing Large Area Chemical Vapor Deposition-Grown Graphene-Based Field-Effect TransistorFront Bioeng Biotechnol. 2018;6:29. doi: 10.3389/fbioe.2018.00029. eCollection 2018. PubMed PMID: 29662878; PubMed Central PMCID: PMC5890177.
Arral ML, Halpern JM. Electrochemical Detection of NG-Hydroxy-L-arginine. ECS Trans. 2018;85(13):1163-1169. doi: 10.1149/08513.1163ecst. PubMed PMID: 30245763; PubMed Central PMCID: PMC6145816.

G. Thompson, S. Marnoto, and J.M. Halpern. "Proper Controls to Electrochemically Evaluate Carotenoids Using β-Cyclodextrin Modified Surfaces." Electrochemical Society Transactions. 80 (2017) 1177-1187.