The CIBBR-sponsored seminar series continues this Friday Sept. 27, featuring Dr. Ricardo Rajsbaum from University of Texas Medical Branch. He will be visiting campus as part of the MCBS Department Seminar sereies and will be providing a lecture from his research.
Topic: Regulation of innate immunity and virus replication by the host ubiquitin system
When & Where: Friday Sept. 27 2019, 12:10 - 1 p.m. in Rudman Hall G89
Abstract: The innate immune response involves activation of multiple signaling pathways that culminate in the production of type I interferons (IFN-I) and inflammatory cytokines, which together control virus infections. However, excessive cytokine production can result in exacerbated disease. To strike the right balance, these signaling pathways are regulated by different molecular processes, including the ubiquitin system. We will discuss novel molecular mechanism by which ubiquitin enzymes regulate host antiviral pathways, and how completely different pathogenic viruses (Nipah, Ebola, Zika and Influenza) repurpose the ubiquitin system to enhance virus replication.
Bio: Ricardo Rajsbaum, Ph.D. is an associate professor in the Department of Microbiology and Immunology at the University of Texas Medical Branch, Galveston, Texas. Dr. Rajsbaum performed his Ph.D. in the laboratory of Anne O’Garra at the MRC-NIMR, London, UK, and completed his postdoctoral training at Mount Sinai School of Medicine, New York, with Dr. Adolfo Garcia-Sastre. Dr. Rajsbaum's lab at UTMB studies the regulation of cytokine expression in immune cells, TLR and RIG-I-like receptor signaling, regulation and function of type-I IFNs, and virus–host interactions, with a specific focus on the role of ubiquitin and TRIM E3-ubiquitin ligases in innate antiviral function.