UNH Resesarchers Study Key Enzyme Related to Vision

UNH Resesarchers Study Key Enzyme Related to Vision

Jun 19, 2014
Three-dimensional model of the PDE enzyme responsible for the first steps in vision.

Rick Cote, professor of molecular, cellular, and biomedical sciences, and his colleagues study the enzyme phosphodiesterase (PDE), the central enzyme in the photoreceptor cells (rods and cones) in the eye that transform light into images. The interdisciplinary research team uses a variety of approaches, including structural biology, proteomics, and biochemical tools, to gain a better understanding of the three-dimensional structure and complex regulation of PDE during the very first steps in the visual signaling pathway.  Mutation of  PDE is a factor in the development of the vision disorder retinitis pigmentosa.

The image at left is a three-dimensional model of the PDE enzyme responsible for the first steps in vision.

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