Thomas Laue

Thomas Laue
Professor
MSP & Molecular, Cellular and Biomedical Sciences
Rudman Hall 379
46 College Road
Durham, NH 03824
(603) 862-2459

Education:

  • BA Natural Sciences, Johns Hopkins University, 1971
  • PhD Biochemistry, University of Connecticut, 1981

Biography:

Tom Laue is known for his expertise in analytical ultracentrifugation and analytical electrophoresis. He is director of the Center to Advance Molecular Interaction Science at the University of New Hampshire, which develops unique instruments and first-principle methods to characterize molecular interactions. In 2001, Dr. Laue founded the Biomolecular Interaction Technologies Center as a National Science Foundation Industry/University Cooperative Research Center. BITC is a consortium of global pharmaceutical firms whose fees support university research and development of novel techniques and technologies for characterizing molecular interactions.

Teaching Interests:

  • Protein Chemistry
  • Biophysical Chemistry

Research Areas:

  1. Analytical instrumentation for characterizing molecular interactions
  2. Intermolecular interactions in complex, high concentration biological systems
  3. Developing ways to measure the effects of proximity energies

Select Publications:

  1. Yadav S, Laue TM, Kalonia D, Singh SN, Shire SJ (2012) “The Influence of Charge Distribution on Self-association and Viscosity Behavior of Monoclonal Antibody Solutions” Mol. Pharmaceutics, 9:791-802.
  2. Kingsbury JS, Laue TM, Chase SF, Connors LH (2012) “Detection of high molecular weight amyloid protein complexes in patient sera using Biological On-Line Tracer Sedimentation (BOLTS)” Anal. Biochem. 425:151-156.
  3. Wang X, Zhang C, Chiang Y-C, Toomey S, Power MP, Granoff ME, Richardson R, Xi W, Lee DJ, Chase S, Laue TM, Denis CL (2012) “Use of the novel technique of analytical ultracentrifugation with fluorescence detection system identifies a 77S monosomal translation complex” Prot. Sci., 21:1253-1268.
  4. Lin H-K, Chase S, Laue, T, Jen-Jacobson L, Trakselis, M (2012) “Differential Temperature Dependent Multimeric Assemblies of Replication and Repair Polymerases on DNA Increase Processivity” Biochemistry, 51:7367-7382.
  5. Laue, TM (2012) “Proximity energies: a framework for understanding concentrated solutions” J. Mol. Recognition, 25:165-173.
  6. Gokarn Y, McClean, Laue TM (2012) “Effect of PEGylation on protein hydrodynamics” Mol. Pharmaceutics, 9:762-773.