| Biochemistry |
BCHM 802 - Endocrinology
Credits:
4.00
Biochemical and molecular structure and function of ’ ·(‚ÿÿÿÿ Biochemical and molecular structure and function of vertebr
vertebrate endocrine systems. Influence of endocrine
systems on the physiology of vertebrates, with special
reference to mammals. Current investigations of the
endocrine systems as a regulator and integrator of body
functions including such systems as growth, reproduction,
metabolism, differentiation, and behavior. Prereq: general
biochemistry or principles of biochemistry;/ or permission.
(Also offered as ANSC 802.) Special fee.
BCHM 811 - Genomics and Bioinformatics
Credits:
4.00
The methods, applications, and implications ofÿ
genomics--the analysis of whole genomes. Microbial, plant
and animal genomics are addressed, as well as medical,
ethical and legal implications. The lab provides exposure
and experience of a range of bioinformatics approaches--the
computer applications used in genome analysis. Prereq:
Principles of Genetics. (Also offered as GEN 811.) Lab.
BCHM 850 - Physical Biochemistry
Credits:
3.00
Structure, interactions, and physical-chemical properties
of biomolecules. Thermodynamic, kinetic, and spectroscopic
methods for the study of proteins and nucleic acids.
Prereq: 2 semesters organic chemistry, 1 semester of
calculus;/ or permission.
BCHM 851 - Principles of Biochemistry I
Credits:
4.00
In-depth survey of biochemistry: macromolecule structure;
structure and function of proteins, nucleic acids,
carbohydrates,and lipids. Prereq: organic chemistry,
general biochemistry or permission.
BCHM 852 - Principles of Biochemistry II
Credits:
4.00
Continuation of in-depth survey of biochemistry:
metabolism of amino acids, nucleotides, carbohydrates and
lipids; macromolecules synthesis and regulation; molecular
biology of the eukaryotic cell. Prereq: BCHM 851 or
permission.
BCHM 854 - Laboratory in Biochemistry and Molecular Biology of Nucleic Acids
Credits:
5.00
Application of modern techniques to the analysis of
biomolecules, with an emphasis on nucleic acids; includes
DNA isolation and analysis, cloning and sequencing and
analysis of gene products. Prereq: general biochemistry,
principles of biochemistry or permission. (Also offered as
GEN 854 and PBIO 854.) Special fee.
BCHM 855 - Laboratory in Biochemistry and Molecular Biology
Credits:
5.00
Application of modern techniques to the characterization
and purification of biomolecules, with an emphasis on
proteins and nucleic acids; analysis of enzyme kinetics;
and basic techniques used in molecular biology. Prereq:
BCHM 851-852;/ or permission. BCHM 852 may be taken
concurrently with BCHM 855. Special fee.
Co-requisites:
BCHM 863 - Biochemistry of Cancer
Credits:
3.00
Molecular mechanisms of viral and chemical carcinogenesis;
role of ocogenes in normal cell growth, development, and
differentiation. Biochemical basis of cancer chemotherapy.
Critical reviews of research papers and an advanced
research paper required. Prereq: general biochemistry or
BCHM 851 or permission. Credit/Fail.
BCHM 866 - Environmental Genomics
Credits:
4.00
The field of environmental genomics uses existing andÿ¿
developing high throughput genomic-scale technologies to
investigate ecological and evolutionary theory, and so
provides a more complete understanding of how organisms
respond to environmental change at the molecular genetic
level. Course covers an array of systems involved in this
emerging field, with the central aim of understanding the
effects of environmental change on genome structure, gene
expression, and adaptive evolutionary change. Information
is derived from the primary literature in the field and
covers practical and technical concepts as well as the
underlying theoretical basis for the major research themes.
Prereq: principles of genetics;/ or permission. (Also
offered as GEN 866.)
BCHM 871 - Molecular Genetics
Credits:
4.00
Structure, organization, replication, dynamics, andð›ÿ¿
expression of genetic information in eukaryotes. Focus on
molecular genetic mechanisms of gene expression and its
control; molecular genetics methods; molecular genetic
control of cell division and differentiation during
development. Prereq: a general biochemistry or principles
of biochemistry course; a course in principles of
genetics;/ or permission. (Also offered as GEN 871.)
BCHM #882 - Developmental Genetics
Credits:
3.00
The molecular genetic basis of metazoan development.›ÿ¿
Course focuses on how genes direct the process of
development and how this problem is analyzed in model
organisms using molecular genetic approaches. Topics
include: control of cell division, maternal factors,
cell-cell interactions, differential gene expression.
Prereq: principles of genetics. (Also offered as GEN 882.)
BCHM 890 - Current Topics in Biomedicine
Credits:
4.00
The dramatic advances in molecular biology andÿ
biochemistry during the last two decades have led to
explosive growth in the accumulation of biomedical
knowledge. To "discover" the literature is an essential
element of training in any molecular discipline in biology.
The first phase of the course will cover the use of
literature search tools, and how to read scientific papers,
write a review and make presentations effectively. The bulk
of the time will be spent on current topics in biomedicine
selected by the class. With guidance from the instructor,
the class will derive reading lists, discuss the
literature, and then write short essays on each topic.
Participants will also prepare a "term" project for
audiovisual presentation to the class in the final two
weeks. Prereq: BIOL 605 or instructor permission.
BCHM 894 - Protein Structure and Function
Credits:
4.00
Analysis of how the three-dimensional architecture ofÿ¿
soluble and membrane proteins contributes to their
biochemical function. Topics include methods for
determining the structure of proteins, protein folding,
protein targeting, and mechanisms of enzyme catalysis.
Computer resources will be used for protein modeling and
structural prediction. Prereq: general biochemistry or
principles of biochemistry.
BCHM 895 - Investigations
Credits:
1.00 to 4.00
Independent study in various areas including but not›ÿ¿
limited to: genetics, signal transduction, gene
regulation, molecular evolution, biochemistry of cancer,
biophysics of macromolecules, endocrinology, and
glycobiology. May include readings, laboratory work,
organized seminars and conferences. Prereq:permission. Not
more than 4 total credit hours can be applied to BCHM or
major electives.
BCHM 897 - Special Topics: Issues in Genome Evolution
Credits:
2.00
This special topics class will involve discussing the›ÿ¿
current literature on genome evolution, with a focus on
underlying population genetic principles.
BCHM 899 - Master's Thesis
Credits:
1.00 to 10.00
May be repeated to a maximum of 10 credits. Cr/F.
BCHM 902 - Endocrine Disruptors/Neuroendocrinology
Credits:
3.00
Biochemical and molecular mechanisms of neurohormones;¿
endocrine disruptors, mechanisms of achons of chemicals
mimicking or interfering with the action of hormones;
potential health effects of endocrine disrupting chemicals;
developmental neuroendocrinology; gene regulator by hormones
BCHM 942 - Biochemical Regulatory Mechanisms
Credits:
3.00
Transcriptional control and post-transcriptional
processing of mRNA; regulation and formation of chromation
structure; mRNA transport; degradation of mRNA nonsense
mediated decay; integration of decay, decapping, and
translational control. Prereq: BCHM 852 or permission.
(Also offered as GEN 942.)
BCHM 950 - Macromolecular Interactions
Credits:
3.00
Interactions between macromolecules are central to all¿
biological processes. Focuses on the structures and
energetics that underlie these processes. Topics include
self-associations, hereto assembly, cooperativity, ligand
linkage and methods for their analysis. Prereq: physical
chemistry I, II or BCHM 850. May be repeated. (Also listed
as MS 910.)
BCHM 960 - Advanced Topics in Signal Transduction
Credits:
3.00
Examination of current topics in signal transduction›ÿ¿
mechanisms. Pathways involving receptor activation,
G-protein activation, regulation of effector enzymes, and
changes in second messengers covered, along with mechanisms
for short- and long-term desensitization of cellular
responses.
BCHM 993 - Advanced Topics in Enzyme Regulatory Mechanisms
Credits:
3.00
Selected topics of current research in the molecular basis
of enzyme regulation. Emphasis on biochemical and
molecular biological approaches to determining the
mechanisms by which key regulatory enzymes are controlled.
Prereq: permission.
BCHM 997 - Seminar
Credits:
1.00
Prereq: permission. Cr/F.
BCHM 998 - Seminar
Credits:
1.00
Prereq: permission. Cr/F.
BCHM 999 - Doctoral Research
Credits:
Cr/F.