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Dr. Becca Hudson-Davies Visiting Scholar (2010)


Becca Hudson-Davies

 

46 College Road
Room 310
Durham, NH 03824
(603) 862-0044

 

Becca completed her PhD at King’s College London, under the supervision of Professor Stuart Milligan, investigating the physiological role of Receptor Interacting Protein 140 (RIP140).  RIP140 is a corepressor of nuclear receptor-regulated gene expression, and the studies identified novel interesting roles for RIP140 in a broad range of functions, including the male reproductive tract, steroidogenesis, adipose tissue, muscle physiology, metabolism, thermoregulation, behavior and development.  Becca has since worked as a research scientist at the Institute of Child Health using shRNA knockdown gene technology to study the role of steroidogenic factor-1 in adrenal cortex development and steroidogenesis.  More recently, Becca has spent time at the University of California Davis and the Woods Hole Oceanographic Institution as a visiting scholar on short-term projects studying the effects of environmental contaminants/endocrine disruptors on fish. 

During her time in Dr Sower’s lab she will be investigating the effects of bisphenol A and estradiol on the hypothalamic-pituitary-gonadal (HPG) axis of the sea lamprey (Petromyzon marinus) by determining their effects on the expression of gonadotrophin-releasing hormone (GnRH) receptors in the pituitary, hypothalamic GnRH concentrations and circulating gonadotropins and thyroid hormones concentrations.  The HPG axis in agnathans has been shown by Stacia Sower and other groups to exhibit a high degree of homology to gnathostomes, but there are also some key morphological and molecular/genetic differences that are still being determined.  Understanding the effects of BPA and estradiol on the expression of GnRH receptors in the lamprey pituitary will contribute to the comparative understanding of the lamprey HPG axis and the potential for endocrine disruption by bisphenol A on these organisms.


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